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T-ignite, 1 for 2 actions
There are two ways of administering T-ignite into the body: intravenous or subcutaneous injection. The mode-of-actions by which T-ignite works varies depending on the administration method. By using the administration methods properly, T-ignite could be a powerful countermeasure against cold tumor.
The function of intravenously administered T-ignite: When administered intravenously, T-ignite rapidly migrates through the bloodstream into cold tumor, and efficiently deliver long peptide antigen to tumor-associated macrophages (TAMs). TAMs received long peptide antigen in T-ignite then initiate antigen presentation to T cells at the tumor local site, leading to the induction of specific T cell infiltration into cold tumor.
The function of subcutaneously administered T-ignite: When administered subcutaneously, T-ignite quickly travels into the draining lymph node through the peripheral lymph vessels, penetrates into the medulla of lymph node, and delivers a large amount of long peptide antigen to medullary macrophages, a new class of professional antigen-presenting cells. Medullary macrophages received T-ignite then strongly activate anti-tumor T cells on an antigen-dependent manner to counter cold tumor (Muraoka, D. et al., ACS Nano 2014).
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