Our Science and Technology
What is T-ignite?
T-ignite is a technology to selectively and strongly activate anti-tumor T cells using long peptide antigen through the action of professional antigen-presenting cells, macrophages. The name T-ignite has the meanings of “T cell igniter” and “tumor microenvironment (TME) igniter”.
T-ignite is made up of two components, long peptide antigen and nanogel-based delivery system.
The function of long peptide antigen: Our chemically synthesized long peptide antigen contained in T-ignite is a sequence of dozens of natural amino acids, and includes multiple T cell epitopes. Macrophages in the body take up T-ignite, extract T cell epitopes from long peptide antigen, and present them to specific anti-tumor T cells, and selectively and strongly activate these T cells. Our long peptide antigen contains multiple T cell epitopes to activate a variety of CD8-positive killer T cells and CD4-positive helper T cells. It is carefully designed to exhibit robust T cell activating effect by utilizing our proprietary sequence optimization technology (patent pending).
The function of nanogel-based delivery system: Our nanogel-based delivery system is a technology for efficient delivery of long peptide antigen to macrophages in the lymph node or the tumor local site. Without this delivery system, long peptide antigen does not exert any effect. Our nanogel is a small spherical hydrogel of about 40 nanometers that is consisting of glucose and cholesterol. It does not have electronic charge and any ligands for phagocytic receptors on its surface. It does not have immune-modulating activity. Thus our nanogel is biologically and immunologically inert allowing it to penetrate into the medulla, a deep area of lymph node or the tumor local site. This material is highly safe and can be administered intravenously and subcutaneously. Various substances such as peptides, proteins and low molecular weight compounds can be loaded inside the nanogel, and the nanogel also functions to solubilize and stabilize these substances.
The importance of adjuvant: In order to maximize the effect of T-ignite, the co-use of adjuvant for stimulating macrophages as antigen-presenting cells is very important. A wide variety of substances that act as adjuvant are known, but we select and use the optimum adjuvant(s) for T-ignite, based on the detailed analysis of mode-of-action of T-ignite.
(Continued to “T-ignite, 1 for 2 actions” on the next page)